If you’ve been anywhere near skincare TikTok, Instagram or a beauty clinic recently, you’ll probably have heard of PDRN and polynucleotides.
And if you’re wondering what on earth they are, you’re definitely not alone.
You may also have heard about the “salmon sperm facial”, which sounds more like something from a very strange episode of I’m a Celebrity than the next big skincare ingredient, but there is actually some interesting science behind it.
PDRN and polynucleotides have become increasingly popular for people who want healthier-looking, smoother, more hydrated skin without dramatically changing their appearance.
But what exactly are they? Do they actually work? What’s the difference between PDRN skincare and injectable polynucleotides? And do you really need salmon DNA on your face?
Let’s keep it simple.
So, what actually is PDRN?
PDRN is short for polydeoxyribonucleotide.
Don’t worry, we’re not going to make you remember that. Put simply, PDRN is made from tiny pieces of DNA.
Traditionally, researchers source these DNA fragments from salmon or trout. They have studied PDRN for years because it may support the body’s natural repair processes.
It has been studied in areas such as wound healing and tissue repair, and more recently it has become a popular ingredient in aesthetic treatments and skincare.
The easiest way to think about it is: PDRN supports the skin as it repairs and renews itself. It’s not replacing your skin. It’s not changing your DNA.
And what are polynucleotides?
This is where things can get confusing because PDRN and polynucleotides are very closely related. They’re both made from DNA building blocks, but they’re not exactly the same thing.
Think of it like this:
PDRN = smaller pieces of DNA
Polynucleotides = longer chains of DNA
When we talk about polynucleotide injections, we mean longer DNA chains that a trained practitioner injects directly into the skin. These chains have high molecular weight so they cannot penetrate the skin, this requires injection.
When we’re speaking of PDRN skincare, we’re usually talking about products such as serums and masks that contain PDRN. This has low molecular weight, so if this is injected, it simply wont do anything. Whereas, in topical skincare products this shows brightening and anti-inflammatory effects. This is faster acting however results wont last as long.
What does PDRN actually do?
This is the more interesting bit!
Researchers have studied PDRN for its role in supporting the skin’s natural repair process. They’re also looking at how PDRN may support collagen, improve skin structure and help reduce inflammation.
For you, that can translate into skin that looks:
- More hydrated
- Plumper
- Smoother
- Healthier
- More even in texture
- More resilient
- Generally a little less tired
The important word here is support.
PDRN isn’t going to magically rebuild your face overnight. Instead, the idea is that it helps create a better environment for your skin to repair and function properly.
Is PDRN the same as a polynucleotides?
PDRN skincare and injectable polynucleotide treatments are not the same thing.
PDRN can be used on the skin in products like serums and masks. In contrast, a qualified practitioner injects polynucleotides directly into the skin during treatment.
Your skin has a very good security system called the skin barrier. Its job is to keep things out. Which is fantastic when it comes to pollution and irritants. But, it’s less helpful when you’re trying to get a skincare ingredient through it.
This is why you shouldn’t expect a PDRN serum to give you exactly the same results as injectable polynucleotides. They are related, but their delivery system and molecular structure are different.
So, what are polynucleotide treatments actually for?
Polynucleotide treatments improve overall skin quality, it doesn’t dramatically change the shape of your face.
They may be suitable if you’re concerned about things such as:
- Fine lines
- Loss of firmness
- Dehydration
- Dullness
- Uneven texture
- Skin that feels less resilient
- General signs of ageing
One of the things people like about polynucleotides is that the aim isn’t to make you look like you’ve had lots of work done. It’s more about getting your skin to look better, healthier and fresher.
What about the “salmon sperm” thing?
Let’s address the elephant, or should we say salmon, in the room.
Traditional PDRN is often from the DNA from salmon or trout. The DNA is purified and processed, so you’re not putting raw salmon anything onto your skin.
The phrase “salmon sperm skincare” has become popular because, let’s face it, it’s a much more attention-grabbing headline than “purified DNA fragments.”
But it can make the whole thing sound much stranger than it actually is. And if you’re vegan, there is another option.
What is vegan PDRN?
Technology has moved on, and PDRN doesn’t necessarily have to come from fish.
Medik8 Exo-PDRN Prismatic+, for example, uses a vegan form of PDRN that is created through biotechnology rather than being sourced from salmon.
Instead of getting the DNA from an animal, the process uses microorganisms to produce the PDRN.
So if you want to try PDRN but don’t want an animal-derived version, vegan PDRN is an option worth knowing about.
What’s the difference between PDRN skincare and polynucleotide injections?
Here’s the easy version:
| PDRN skincare | Polynucleotide treatment | |
|---|---|---|
| How is it used? | Applied to the skin | Injected into the skin |
| Where does it work? | Mainly at the skin’s surface | Deeper within the skin |
| Best for | Supporting your skincare routine | More intensive skin rejuvenation |
| Results | More subtle and supportive | More noticeable improvement in skin quality |
| Professional treatment? | No | Yes |
| Is It Vegan? | Not usually, but there are now Vegan PDRN skincare available now. | No. But following consultation, the practitioner may be able to offer alternative injectable treatments. |
You could even use topical PDRN skincare alongside professional treatments as part of your ongoing skincare routine.
Can you use PDRN at home?
Absolutely. There are now plenty of PDRN products available for home use, including serums, creams and masks.
Brand New Ameela PDRN Mask is one option, which is a simple way to add PDRN into your routine when your skin needs a little extra hydration and TLC. It’s particularly useful as a supportive step between professional treatments.
There’s also Medik8 Exo-PDRN Prismatic+. This is a vegan PDRN product that combines PDRN with exosomes and other skin-supporting ingredients, making it more of an advanced treatment product rather than simply another moisturiser.
Are PDRN and polynucleotides safe?
PDRN and polynucleotides have generally been well tolerated in studies and clinical use. But, as with any skincare ingredient or aesthetic treatment, there can be individual differences.
Topical products and injectable treatments should also be considered separately.
If you’re having injectable polynucleotide treatment, it should always be carried out by a suitably trained practitioner following a consultation.
You should also tell your practitioner about any relevant medical history, medication or allergies before treatment.
Can you use PDRN with other skincare?
Generally, yes. PDRN can be used alongside many of the ingredients you may already have in your routine. See it as an addition to your skincare regime, not a replacement.
Have you got more questions about PDRN or polynucleotides? You can contact us or read more here: